Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Thomas F Hansen; Klaus D Jakobsen; Mogens Fenger; Jimmi Nielsen; Karoline Krane; Anders Fink-Jensen; Henrik Lublin; Henrik Ullum; Sally Timm; August G. Wang; Niklas Rye Jørgensen; Thomas Werge

doi:10.1016/j.schres.2008.05.026

Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Thomas F Hansen, Klaus D Jakobsen, Mogens Fenger, Jimmi Nielsen, Karoline Krane, Anders Fink-Jensen, Henrik Lublin, Henrik Ullum, Sally Timm, August G. Wang, Niklas Rye Jørgensen, Thomas Werge

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.

Original language	English
Pages (from-to)	146-152
Number of pages	7
Journal	Schizophrenia Research
Volume	104
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2008.05.026
Publication status	Published - 2008

Keywords

adult
aged 80 and over
alleles
Denmark
european continental ancestry group
female
genetic variation
genotype
humans
male
middle aged
polymorphism
single nucleotide
receptors
purinergic P2
schizophrenia
young adult
P2XR7
Treatment resistance
Register data

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10.1016/j.schres.2008.05.026

https://reader.elsevier.com/reader/sd/pii/S0920996408002430?token=482B789A3FC5DB2E520C6AE285663E83EE83DBA7A1FFF0B8156E48D9ADB024C9C4FC80D44847D6ABFF907352446A938A&originRegion=eu-west-1&originCreation=20220621152819

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@article{021514b8f5eb4273ac326b639a05aec1,

title = "Variation in the purinergic P2RX(7) receptor gene and schizophrenia",

abstract = "INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.",

keywords = "adult, aged 80 and over, alleles, Denmark, european continental ancestry group, female, genetic variation, genotype, humans, male, middle aged, polymorphism, single nucleotide, receptors, purinergic P2, schizophrenia, young adult, P2XR7, Treatment resistance, Register data",

author = "Hansen, {Thomas F} and Jakobsen, {Klaus D} and Mogens Fenger and Jimmi Nielsen and Karoline Krane and Anders Fink-Jensen and Henrik Lublin and Henrik Ullum and Sally Timm and Wang, {August G.} and J{\o}rgensen, {Niklas Rye} and Thomas Werge",

year = "2008",

doi = "10.1016/j.schres.2008.05.026",

language = "English",

volume = "104",

pages = "146--152",

journal = "Schizophrenia Research",

issn = "1573-2509",

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number = "1-3",

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T1 - Variation in the purinergic P2RX(7) receptor gene and schizophrenia

AU - Hansen, Thomas F

AU - Jakobsen, Klaus D

AU - Fenger, Mogens

AU - Nielsen, Jimmi

AU - Krane, Karoline

AU - Fink-Jensen, Anders

AU - Lublin, Henrik

AU - Ullum, Henrik

AU - Timm, Sally

AU - Wang, August G.

AU - Jørgensen, Niklas Rye

AU - Werge, Thomas

PY - 2008

Y1 - 2008

N2 - INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.

AB - INTRODUCTION: The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia. METHODS: Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls. RESULTS: We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. CONCLUSION: P2XR(7) was not associated with schizophrenia in this study.

KW - adult

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KW - alleles

KW - Denmark

KW - european continental ancestry group

KW - female

KW - genetic variation

KW - genotype

KW - humans

KW - male

KW - middle aged

KW - polymorphism

KW - single nucleotide

KW - receptors

KW - purinergic P2

KW - schizophrenia

KW - young adult

KW - P2XR7

KW - Treatment resistance

KW - Register data

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M3 - Article

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SN - 1573-2509

VL - 104

SP - 146

EP - 152

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Variation in the purinergic P2RX(7) receptor gene and schizophrenia

Abstract

Keywords

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