Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study

Erik G Jönsson; Kristina Larsson; Maria Vares; Thomas F Hansen; August G. Wang; Srdjan Djurovic; Kjersti S Rønningen; Ole A Andreassen; Ingrid Agartz; Thomas Werge; Lars Terenius; Håkan Hall

doi:10.1002/ajmg.b.30671

Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study

Erik G Jönsson, Kristina Larsson, Maria Vares, Thomas F Hansen, August G. Wang, Srdjan Djurovic, Kjersti S Rønningen, Ole A Andreassen, Ingrid Agartz, Thomas Werge, Lars Terenius, Håkan Hall

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships.

Original language	English
Pages (from-to)	976-982
Number of pages	7
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	147B
Issue number	6
DOIs	https://doi.org/10.1002/ajmg.b.30671
Publication status	Published - 2008

Keywords

adult
aged
bipolar disorders
case-control studies
cohort studies
female
gene frequency
genotype
Linkage disequilibrium
male
meta-analysis as topic
Methylenetetrahydrofolate Reductase (NADPH2)
middle aged
polymorphism
single nucleotide
schizophrenia

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Jönsson, E. G., Larsson, K., Vares, M., Hansen, T. F., Wang, A. G., Djurovic, S., Rønningen, K. S., Andreassen, O. A., Agartz, I., Werge, T., Terenius, L., & Hall, H. (2008). Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B(6), 976-982. https://doi.org/10.1002/ajmg.b.30671

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title = "Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study",

abstract = "Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships.",

keywords = "adult, aged, bipolar disorders, case-control studies, cohort studies, female, gene frequency, genotype, Linkage disequilibrium, male, meta-analysis as topic, Methylenetetrahydrofolate Reductase (NADPH2), middle aged, polymorphism, single nucleotide, schizophrenia",

author = "J{\"o}nsson, {Erik G} and Kristina Larsson and Maria Vares and Hansen, {Thomas F} and Wang, {August G.} and Srdjan Djurovic and R{\o}nningen, {Kjersti S} and Andreassen, {Ole A} and Ingrid Agartz and Thomas Werge and Lars Terenius and H{\aa}kan Hall",

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doi = "10.1002/ajmg.b.30671",

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Jönsson, EG, Larsson, K, Vares, M, Hansen, TF, Wang, AG, Djurovic, S, Rønningen, KS, Andreassen, OA, Agartz, I, Werge, T, Terenius, L & Hall, H 2008, 'Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 147B, no. 6, pp. 976-982. https://doi.org/10.1002/ajmg.b.30671

TY - JOUR

T1 - Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder

T2 - an association study

AU - Jönsson, Erik G

AU - Larsson, Kristina

AU - Vares, Maria

AU - Hansen, Thomas F

AU - Wang, August G.

AU - Djurovic, Srdjan

AU - Rønningen, Kjersti S

AU - Andreassen, Ole A

AU - Agartz, Ingrid

AU - Werge, Thomas

AU - Terenius, Lars

AU - Hall, Håkan

N1 - Brief research communication

PY - 2008

Y1 - 2008

N2 - Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships.

AB - Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships.

KW - adult

KW - aged

KW - bipolar disorders

KW - case-control studies

KW - cohort studies

KW - female

KW - gene frequency

KW - genotype

KW - Linkage disequilibrium

KW - male

KW - meta-analysis as topic

KW - Methylenetetrahydrofolate Reductase (NADPH2)

KW - middle aged

KW - polymorphism

KW - single nucleotide

KW - schizophrenia

UR - https://research.regionh.dk/en/publications/two-methylenetetrahydrofolate-reductase-gene-mthfr-polymorphisms-schizophrenia-and-bipolar-disorder(03f08435-311b-4cac-ae65-1ccc56a4778a).html

U2 - 10.1002/ajmg.b.30671

DO - 10.1002/ajmg.b.30671

M3 - Article

C2 - 18165967

SN - 1552-485X

VL - 147B

SP - 976

EP - 982

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 6

ER -

Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study

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