TY - JOUR
T1 - The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson's disease in the Faroe Islands
AU - Petersen, Maria Skaalum
AU - Bech, Sára
AU - Christiansen, Debes H.
AU - Schmedes, Anna Vibeke
AU - Halling, Jónrit
PY - 2014/2
Y1 - 2014/2
N2 - The role of vitamin D in Parkinson's disease (PD) has been proposed and both low serum 25-hydroxyvitamin D levels (25(OH)D) and vitamin D receptor polyrnorphisms (VDR) have been linked to PD. The aim of this study is to investigate the associations among 25(OH)D and three VDR polymorphisms and PD in the Faroese population where the prevalence of PD is high. We conducted a case-control study where 121 cases were studied for 25(OH)D levels and VDR polymorphisms against 235 randomly selected controls, matched by gender and age. No significant difference was observed in 25(OH)D levels between PD cases and controls (P = 0.49), although cases had slightly lower values than controls. As well, no differences were found in genotype frequencies between cases and controls in the VDR polymorphisms studied (ApaI, BsmI, TaqI) (P = 0.70, P = 0.56 and P = 0.54, respectively). However, we found that VDR ApaI/AC genotype was significantly associated with 25(OH)D levels (P = 0.01). Although our results indicate no association between PD and vitamin D polymorphisms and/or 25(OH)D levels, the study cannot exclude a weak association. However, the known doubling in PD prevalence in the Faroe Islands cannot be explained by the polymorphisms examined in the VDR gene or the 25(OH)D levels and has to be explored further. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
AB - The role of vitamin D in Parkinson's disease (PD) has been proposed and both low serum 25-hydroxyvitamin D levels (25(OH)D) and vitamin D receptor polyrnorphisms (VDR) have been linked to PD. The aim of this study is to investigate the associations among 25(OH)D and three VDR polymorphisms and PD in the Faroese population where the prevalence of PD is high. We conducted a case-control study where 121 cases were studied for 25(OH)D levels and VDR polymorphisms against 235 randomly selected controls, matched by gender and age. No significant difference was observed in 25(OH)D levels between PD cases and controls (P = 0.49), although cases had slightly lower values than controls. As well, no differences were found in genotype frequencies between cases and controls in the VDR polymorphisms studied (ApaI, BsmI, TaqI) (P = 0.70, P = 0.56 and P = 0.54, respectively). However, we found that VDR ApaI/AC genotype was significantly associated with 25(OH)D levels (P = 0.01). Although our results indicate no association between PD and vitamin D polymorphisms and/or 25(OH)D levels, the study cannot exclude a weak association. However, the known doubling in PD prevalence in the Faroe Islands cannot be explained by the polymorphisms examined in the VDR gene or the 25(OH)D levels and has to be explored further. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
KW - Parkinson's disease
KW - vitamin D receptor
KW - polymorphism
KW - Faroe Islands
KW - CHINESE HAN POPULATION
KW - GENE POLYMORPHISMS
KW - HIGH PREVALENCE
KW - 25-HYDROXYVITAMIN D
KW - ASSOCIATION
KW - RISK
KW - BONE
UR - http://dx.doi.org/10.1016/j.neulet.2013.12.053
U2 - 10.1016/j.neulet.2013.12.053
DO - 10.1016/j.neulet.2013.12.053
M3 - Article
SN - 0304-3940
VL - 561
SP - 74
EP - 79
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -