The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells

E. Rivedal; S.-O. Mikalsen; T. Sanner

doi:10.1016/0006-291X(90)90665-A

The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells

E. Rivedal, S.-O. Mikalsen, T. Sanner

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Okadaic acid is a potent non-phorbol ester mouse skin tumor promoter. Unlike the phorbol ester tumor promoters, okadaic acid is unable to promote the induction of morphological transformation in Syrian hamster embryo cell colonies. On the contrary, okadaic acid seems to counteract the effect of phorbol esters on transformation. Also unlike phorbol ester tumor promoters, okadaic acid does not inhibit intercellular communication, neither in primary hamster embryo cells, nor in the phorbol ester sensitive cell line BPNi. Furthermore, okadaic acid has no effect on the reoccurrence of communication following removal of 12-O-tetradecanoylphorbol-13-acetate.

Original language	English
Pages (from-to)	1302-1308
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	167
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(90)90665-A
Publication status	Published - 1990
Externally published	Yes

Keywords

Okadaic acid
Diarrhetic shellfish poison
In vitro assays
gap junctional intercellular communication

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10.1016/0006-291X(90)90665-A

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title = "The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells",

abstract = "Okadaic acid is a potent non-phorbol ester mouse skin tumor promoter. Unlike the phorbol ester tumor promoters, okadaic acid is unable to promote the induction of morphological transformation in Syrian hamster embryo cell colonies. On the contrary, okadaic acid seems to counteract the effect of phorbol esters on transformation. Also unlike phorbol ester tumor promoters, okadaic acid does not inhibit intercellular communication, neither in primary hamster embryo cells, nor in the phorbol ester sensitive cell line BPNi. Furthermore, okadaic acid has no effect on the reoccurrence of communication following removal of 12-O-tetradecanoylphorbol-13-acetate.",

keywords = "Okadaic acid, Diarrhetic shellfish poison, In vitro assays, gap junctional intercellular communication",

author = "E. Rivedal and S.-O. Mikalsen and T. Sanner",

year = "1990",

doi = "10.1016/0006-291X(90)90665-A",

language = "English",

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journal = "Biochemical and Biophysical Research Communications",

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AU - Rivedal, E.

AU - Mikalsen, S.-O.

AU - Sanner, T.

PY - 1990

Y1 - 1990

N2 - Okadaic acid is a potent non-phorbol ester mouse skin tumor promoter. Unlike the phorbol ester tumor promoters, okadaic acid is unable to promote the induction of morphological transformation in Syrian hamster embryo cell colonies. On the contrary, okadaic acid seems to counteract the effect of phorbol esters on transformation. Also unlike phorbol ester tumor promoters, okadaic acid does not inhibit intercellular communication, neither in primary hamster embryo cells, nor in the phorbol ester sensitive cell line BPNi. Furthermore, okadaic acid has no effect on the reoccurrence of communication following removal of 12-O-tetradecanoylphorbol-13-acetate.

AB - Okadaic acid is a potent non-phorbol ester mouse skin tumor promoter. Unlike the phorbol ester tumor promoters, okadaic acid is unable to promote the induction of morphological transformation in Syrian hamster embryo cell colonies. On the contrary, okadaic acid seems to counteract the effect of phorbol esters on transformation. Also unlike phorbol ester tumor promoters, okadaic acid does not inhibit intercellular communication, neither in primary hamster embryo cells, nor in the phorbol ester sensitive cell line BPNi. Furthermore, okadaic acid has no effect on the reoccurrence of communication following removal of 12-O-tetradecanoylphorbol-13-acetate.

KW - Okadaic acid

KW - Diarrhetic shellfish poison

KW - In vitro assays

KW - gap junctional intercellular communication

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DO - 10.1016/0006-291X(90)90665-A

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EP - 1308

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells

Abstract

Keywords

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