The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications

Mads H Haugen, Kjersti Flatmark, Svein-Ole Mikalsen, Gunhild M Malandsmo

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

S100A4 is a metastasis-associated protein which has been linked to multiple cellular events, and has been identified extracellularly, in the cytoplasm and in the nucleus of tumor cells; however, the biological implications of subcellular location are unknown. Associations between a variety of posttranslational protein modifications and altered biological functions of proteins are becoming increasingly evident. Identification and characterization of posttranslationally modified S100A4 variants could thus contribute to elucidating the mechanisms for the many cellular functions that have been reported for this protein, and might eventually lead to the identification of novel drugable targets.
Original languageEnglish
Article number172
JournalBMC Cancer
Volume81
DOIs
Publication statusPublished - Jun 2008

Keywords

  • S100A4
  • protein

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