Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitus: A prospective cohort study

Mengying Li; Shanshan Li; Jorge E. Chavarro; Audrey J. Gaskins; Sylvia H. Ley; Stefanie N. Hinkle; Xiaobin Wang; Ming Ding; Griffith Bell; Anne A. Bjerregaard; Sjurdur F. Olsen; James L. Mills; Frank B. Hu; Cuilin Zhang

doi:10.2337/dc18-2198

Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitus: A prospective cohort study

Mengying Li, Shanshan Li, Jorge E. Chavarro, Audrey J. Gaskins, Sylvia H. Ley, Stefanie N. Hinkle, Xiaobin Wang, Ming Ding, Griffith Bell, Anne A. Bjerregaard, Sjurdur F. Olsen, James L. Mills, Frank B. Hu, Cuilin Zhang

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

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Abstract

OBJECTIVE To identify novel modifiable risk factors of gestational diabetes mellitus (GDM) by examining the association between prepregnancy habitual folate intake and GDM risk. RESEARCH DESIGN AND METHODS The study included 14,553 women in the Nurses’ Health Study II who reported at least one singleton pregnancy between the 1991 and 2001 questionnaires. Prepregnancy intakes of total folate, supplemental folate, and food folate were assessed using a food frequency questionnaire administered every 4 years. Incident GDM was ascertained from a self-reported physician diagnosis. Relative risks (RRs) of GDM were estimated using log-binomial models, with adjustment for demographic, lifestyle, and dietary factors. RESULTS Over the study follow-up, 824 incident GDM cases were reported among 20,199 pregnancies. Women with adequate total folate intake (‡400 mg/day) had an RR of GDM of 0.83 (95% CI 0.72, 0,95, P = 0.007) compared with women with inadequate intake (

Original language	English
Pages (from-to)	1034-1041
Number of pages	8
Journal	Diabetes Care
Volume	42
Issue number	6
DOIs	https://doi.org/10.2337/dc18-2198
Publication status	Published - Jun 2019

Keywords

pregnancy
women
food folate
gestational diabetes mellitus
cohort study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc18-2198

Li M et al Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitusFinal published version, 731 KB

http://europepmc.org/article/med/31010874

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Li, M., Li, S., Chavarro, J. E., Gaskins, A. J., Ley, S. H., Hinkle, S. N., Wang, X., Ding, M., Bell, G., Bjerregaard, A. A., Olsen, S. F., Mills, J. L., Hu, F. B., & Zhang, C. (2019). Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitus: A prospective cohort study. Diabetes Care, 42(6), 1034-1041. https://doi.org/10.2337/dc18-2198

@article{d490669bb55b49cdb22630f3fd4be3f0,

title = "Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitus: A prospective cohort study",

abstract = "OBJECTIVE To identify novel modifiable risk factors of gestational diabetes mellitus (GDM) by examining the association between prepregnancy habitual folate intake and GDM risk. RESEARCH DESIGN AND METHODS The study included 14,553 women in the Nurses{\textquoteright} Health Study II who reported at least one singleton pregnancy between the 1991 and 2001 questionnaires. Prepregnancy intakes of total folate, supplemental folate, and food folate were assessed using a food frequency questionnaire administered every 4 years. Incident GDM was ascertained from a self-reported physician diagnosis. Relative risks (RRs) of GDM were estimated using log-binomial models, with adjustment for demographic, lifestyle, and dietary factors. RESULTS Over the study follow-up, 824 incident GDM cases were reported among 20,199 pregnancies. Women with adequate total folate intake (‡400 mg/day) had an RR of GDM of 0.83 (95% CI 0.72, 0,95, P = 0.007) compared with women with inadequate intake (",

keywords = "pregnancy, women, food folate, gestational diabetes mellitus, cohort study",

author = "Mengying Li and Shanshan Li and Chavarro, {Jorge E.} and Gaskins, {Audrey J.} and Ley, {Sylvia H.} and Hinkle, {Stefanie N.} and Xiaobin Wang and Ming Ding and Griffith Bell and Bjerregaard, {Anne A.} and Olsen, {Sjurdur F.} and Mills, {James L.} and Hu, {Frank B.} and Cuilin Zhang",

note = "Publisher Copyright: {\textcopyright} 2019 by the American Diabetes Association. Unless otherwise indicated, Scholarly articles published by ADA are freely accessible online 12 months after the print publication date.",

year = "2019",

month = jun,

doi = "10.2337/dc18-2198",

language = "English",

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pages = "1034--1041",

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issn = "1935-5548",

publisher = "American Diabetes Association Inc.",

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Li, M, Li, S, Chavarro, JE, Gaskins, AJ, Ley, SH, Hinkle, SN, Wang, X, Ding, M, Bell, G, Bjerregaard, AA, Olsen, SF, Mills, JL, Hu, FB & Zhang, C 2019, 'Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitus: A prospective cohort study', Diabetes Care, vol. 42, no. 6, pp. 1034-1041. https://doi.org/10.2337/dc18-2198

TY - JOUR

T1 - Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitus

T2 - A prospective cohort study

AU - Li, Mengying

AU - Li, Shanshan

AU - Chavarro, Jorge E.

AU - Gaskins, Audrey J.

AU - Ley, Sylvia H.

AU - Hinkle, Stefanie N.

AU - Wang, Xiaobin

AU - Ding, Ming

AU - Bell, Griffith

AU - Bjerregaard, Anne A.

AU - Olsen, Sjurdur F.

AU - Mills, James L.

AU - Hu, Frank B.

AU - Zhang, Cuilin

N1 - Publisher Copyright: © 2019 by the American Diabetes Association. Unless otherwise indicated, Scholarly articles published by ADA are freely accessible online 12 months after the print publication date.

PY - 2019/6

Y1 - 2019/6

N2 - OBJECTIVE To identify novel modifiable risk factors of gestational diabetes mellitus (GDM) by examining the association between prepregnancy habitual folate intake and GDM risk. RESEARCH DESIGN AND METHODS The study included 14,553 women in the Nurses’ Health Study II who reported at least one singleton pregnancy between the 1991 and 2001 questionnaires. Prepregnancy intakes of total folate, supplemental folate, and food folate were assessed using a food frequency questionnaire administered every 4 years. Incident GDM was ascertained from a self-reported physician diagnosis. Relative risks (RRs) of GDM were estimated using log-binomial models, with adjustment for demographic, lifestyle, and dietary factors. RESULTS Over the study follow-up, 824 incident GDM cases were reported among 20,199 pregnancies. Women with adequate total folate intake (‡400 mg/day) had an RR of GDM of 0.83 (95% CI 0.72, 0,95, P = 0.007) compared with women with inadequate intake (

AB - OBJECTIVE To identify novel modifiable risk factors of gestational diabetes mellitus (GDM) by examining the association between prepregnancy habitual folate intake and GDM risk. RESEARCH DESIGN AND METHODS The study included 14,553 women in the Nurses’ Health Study II who reported at least one singleton pregnancy between the 1991 and 2001 questionnaires. Prepregnancy intakes of total folate, supplemental folate, and food folate were assessed using a food frequency questionnaire administered every 4 years. Incident GDM was ascertained from a self-reported physician diagnosis. Relative risks (RRs) of GDM were estimated using log-binomial models, with adjustment for demographic, lifestyle, and dietary factors. RESULTS Over the study follow-up, 824 incident GDM cases were reported among 20,199 pregnancies. Women with adequate total folate intake (‡400 mg/day) had an RR of GDM of 0.83 (95% CI 0.72, 0,95, P = 0.007) compared with women with inadequate intake (

KW - pregnancy

KW - women

KW - food folate

KW - gestational diabetes mellitus

KW - cohort study

U2 - 10.2337/dc18-2198

DO - 10.2337/dc18-2198

M3 - Article

SN - 1935-5548

VL - 42

SP - 1034

EP - 1041

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -

Prepregnancy habitual intakes of total, supplemental, and food folate and risk of gestational diabetes mellitus: A prospective cohort study

Abstract

Keywords

UN SDGs

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