Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20years of age

S Hansen; M Strom; SF Olsen; R Dahl; HJ Hoffmann; C Granstrom; D Rytter; BH Bech; A Linneberg; E Maslova; H Kiviranta; P Rantakokko; TI Halldorsson

doi:10.1111/cea.12631

Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20years of age

S Hansen, M Strom, SF Olsen, R Dahl, HJ Hoffmann, C Granstrom, D Rytter, BH Bech, A Linneberg, E Maslova, H Kiviranta, P Rantakokko, TI Halldorsson

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Abstract

Background

Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.

Methods

In a Danish cohort of 965 pregnant women established in 1988–1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p’-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kU_A/L) (n = 418) and lung function [forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC)] (n = 414).

Results

There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV₁/FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14–7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p’-DDE were 2.68 (1.06–6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV₁% of predicted value < 90%).

Conclusion and Clinical Relevance

Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.

Original language	English
Pages (from-to)	329-336
Number of pages	8
Journal	Clinical and experimental Allergy
Volume	46
Issue number	2
DOIs	https://doi.org/10.1111/cea.12631
Publication status	Published - 2016

Keywords

persistent organic pollutants (POPs)
prenatal exposure
allergic sensitization
lung function

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10.1111/cea.12631

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Hansen, S., Strom, M., Olsen, SF., Dahl, R., Hoffmann, HJ., Granstrom, C., Rytter, D., Bech, BH., Linneberg, A., Maslova, E., Kiviranta, H., Rantakokko, P., & Halldorsson, TI. (2016). Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20years of age. Clinical and experimental Allergy, 46(2), 329-336. https://doi.org/10.1111/cea.12631

@article{7476e2cb32a34da6a426ab01ea1ed9c9,

title = "Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20years of age",

abstract = " Background Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring. Methods In a Danish cohort of 965 pregnant women established in 1988–1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p{\textquoteright}-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA/L) (n = 418) and lung function [forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)] (n = 414). Results There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1/FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14–7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p{\textquoteright}-DDE were 2.68 (1.06–6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1% of predicted value < 90%). Conclusion and Clinical Relevance Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life. ",

keywords = "persistent organic pollutants (POPs), prenatal exposure, allergic sensitization, lung function",

author = "S Hansen and M Strom and SF Olsen and R Dahl and HJ Hoffmann and C Granstrom and D Rytter and BH Bech and A Linneberg and E Maslova and H Kiviranta and P Rantakokko and TI Halldorsson",

year = "2016",

doi = "10.1111/cea.12631",

language = "English",

volume = "46",

pages = "329--336",

journal = "Clinical and experimental Allergy",

issn = "0954-7894",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

Hansen, S, Strom, M , Olsen, SF, Dahl, R, Hoffmann, HJ, Granstrom, C, Rytter, D, Bech, BH, Linneberg, A, Maslova, E, Kiviranta, H, Rantakokko, P & Halldorsson, TI 2016, 'Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20years of age', Clinical and experimental Allergy, vol. 46, no. 2, pp. 329-336. https://doi.org/10.1111/cea.12631

TY - JOUR

T1 - Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20years of age

AU - Hansen, S

AU - Strom, M

AU - Olsen, SF

AU - Dahl, R

AU - Hoffmann, HJ

AU - Granstrom, C

AU - Rytter, D

AU - Bech, BH

AU - Linneberg, A

AU - Maslova, E

AU - Kiviranta, H

AU - Rantakokko, P

AU - Halldorsson, TI

PY - 2016

Y1 - 2016

N2 - Background Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring. Methods In a Danish cohort of 965 pregnant women established in 1988–1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p’-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA/L) (n = 418) and lung function [forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)] (n = 414). Results There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1/FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14–7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p’-DDE were 2.68 (1.06–6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1% of predicted value < 90%). Conclusion and Clinical Relevance Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.

AB - Background Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring. Methods In a Danish cohort of 965 pregnant women established in 1988–1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p’-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA/L) (n = 418) and lung function [forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)] (n = 414). Results There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1/FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14–7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p’-DDE were 2.68 (1.06–6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1% of predicted value < 90%). Conclusion and Clinical Relevance Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.

KW - persistent organic pollutants (POPs)

KW - prenatal exposure

KW - allergic sensitization

KW - lung function

UR - https://europepmc.org/article/med/26333063

U2 - 10.1111/cea.12631

DO - 10.1111/cea.12631

M3 - Article

SN - 0954-7894

VL - 46

SP - 329

EP - 336

JO - Clinical and experimental Allergy

JF - Clinical and experimental Allergy

IS - 2

ER -

Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20years of age

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Keywords

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