PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER

AG Vang; SZ Ben-Sasson; H Dong; B Kream; MP DeNinno; MM Claffey; W Housley; RB Clark; PM Epstein; S Brocke

doi:10.1371/journal.pone.0012011

PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER

AG Vang, SZ Ben-Sasson, H Dong, B Kream, MP DeNinno, MM Claffey, W Housley, RB Clark, PM Epstein, S Brocke

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Abstract

Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than PDE4. Thus, we postulated that PDE8 is an important regulator of Teff cell functions.

Original language	English
Pages (from-to)	1-13
Journal	PloS one
Volume	5
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0012011
Publication status	Published - Aug 2010

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10.1371/journal.pone.0012011

Vang, AG et al PDE8 Regulates Rapid Teff Cell Adhesion andFinal published version, 777 KB

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abstract = "Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than PDE4. Thus, we postulated that PDE8 is an important regulator of Teff cell functions.",

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AU - Ben-Sasson, SZ

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AU - Kream, B

AU - DeNinno, MP

AU - Claffey, MM

AU - Housley, W

AU - Clark, RB

AU - Epstein, PM

AU - Brocke, S

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AB - Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than PDE4. Thus, we postulated that PDE8 is an important regulator of Teff cell functions.

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PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER

Abstract

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