Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

Deven M. Patel; Rena R. Jones; Benjamin J. Booth; Ann C. Olsson; Hans Kromhout; Kurt Straif; Roel Vermeulen; Gabriella Tikellis; Ora Paltiel; Jean Golding; Kate Northstone; Camilla Stoltenberg; Siri E. Håberg; Joachim Schüz; Melissa C. Friesen; Anne Louise Ponsonby; Stanley Lemeshow; Martha S. Linet; Per Magnus; Jørn Olsen; Sjurdur F. Olsen; Terence Dwyer; Leslie T. Stayner; Mary H. Ward; on behalf of the International Childhood Cancer Cohort Consortium

doi:10.1002/ijc.32388

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

Deven M. Patel, Rena R. Jones, Benjamin J. Booth, Ann C. Olsson, Hans Kromhout, Kurt Straif, Roel Vermeulen, Gabriella Tikellis, Ora Paltiel, Jean Golding, Kate Northstone, Camilla Stoltenberg, Siri E. Håberg, Joachim Schüz, Melissa C. Friesen, Anne Louise Ponsonby, Stanley Lemeshow, Martha S. Linet, Per Magnus, Jørn OlsenSjurdur F. Olsen, Terence Dwyer, Leslie T. Stayner, Mary H. Ward, on behalf of the International Childhood Cancer Cohort Consortium

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood
cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood
leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on
329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental
occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job
codes to the ALOHA+ job exposure matrix. Risk of childhood (myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate
hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased
risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals
HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with
AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS
tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant
associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational
exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL
associated with maternal and paternal organic dust exposures should be investigated further.

Original language	English
Pages (from-to)	943-952
Number of pages	10
Journal	International Journal of Cancer
Volume	146
Issue number	4
DOIs	https://doi.org/10.1002/ijc.32388
Publication status	Published - May 2019

Keywords

agricultural exposures
animals
childhood brain tumors
childhood cancer
childhood leukemia
organic dust
parental occupation
pesticides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Patel, D. M., Jones, R. R., Booth, B. J., Olsson, A. C., Kromhout, H., Straif, K., Vermeulen, R., Tikellis, G., Paltiel, O., Golding, J., Northstone, K., Stoltenberg, C., Håberg, S. E., Schüz, J., Friesen, M. C., Ponsonby, A. L., Lemeshow, S., Linet, M. S., Magnus, P., ... Consortium, O. B. O. T. I. C. C. C. (2019). Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). International Journal of Cancer, 146(4), 943-952. https://doi.org/10.1002/ijc.32388

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title = "Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)",

abstract = "Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhoodcancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhoodleukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parentaloccupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 jobcodes to the ALOHA+ job exposure matrix. Risk of childhood (myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generatehazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increasedrisk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animalsHR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated withAML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNStumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significantassociations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupationalexposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALLassociated with maternal and paternal organic dust exposures should be investigated further.",

keywords = "agricultural exposures, animals, childhood brain tumors, childhood cancer, childhood leukemia, organic dust, parental occupation, pesticides",

author = "Patel, {Deven M.} and Jones, {Rena R.} and Booth, {Benjamin J.} and Olsson, {Ann C.} and Hans Kromhout and Kurt Straif and Roel Vermeulen and Gabriella Tikellis and Ora Paltiel and Jean Golding and Kate Northstone and Camilla Stoltenberg and H{\aa}berg, {Siri E.} and Joachim Sch{\"u}z and Friesen, {Melissa C.} and Ponsonby, {Anne Louise} and Stanley Lemeshow and Linet, {Martha S.} and Per Magnus and J{\o}rn Olsen and Olsen, {Sjurdur F.} and Terence Dwyer and Stayner, {Leslie T.} and Ward, {Mary H.} and Consortium, {on behalf of the International Childhood Cancer Cohort}",

note = "Publisher Copyright: {\textcopyright} 2019 UICC",

year = "2019",

month = may,

doi = "10.1002/ijc.32388",

language = "English",

volume = "146",

pages = "943--952",

journal = "International Journal of Cancer",

issn = "1097-0215",

publisher = "John Wiley & Sons",

number = "4",

}

Patel, DM, Jones, RR, Booth, BJ, Olsson, AC, Kromhout, H, Straif, K, Vermeulen, R, Tikellis, G, Paltiel, O, Golding, J, Northstone, K, Stoltenberg, C, Håberg, SE, Schüz, J, Friesen, MC, Ponsonby, AL, Lemeshow, S, Linet, MS, Magnus, P, Olsen, J, Olsen, SF, Dwyer, T, Stayner, LT, Ward, MH & Consortium, OBOTICCC 2019, 'Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)', International Journal of Cancer, vol. 146, no. 4, pp. 943-952. https://doi.org/10.1002/ijc.32388

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). / Patel, Deven M.; Jones, Rena R.; Booth, Benjamin J. et al.
In: International Journal of Cancer, Vol. 146, No. 4, 05.2019, p. 943-952.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors

T2 - Findings from the International Childhood Cancer Cohort Consortium (I4C)

AU - Patel, Deven M.

AU - Jones, Rena R.

AU - Booth, Benjamin J.

AU - Olsson, Ann C.

AU - Kromhout, Hans

AU - Straif, Kurt

AU - Vermeulen, Roel

AU - Tikellis, Gabriella

AU - Paltiel, Ora

AU - Golding, Jean

AU - Northstone, Kate

AU - Stoltenberg, Camilla

AU - Håberg, Siri E.

AU - Schüz, Joachim

AU - Friesen, Melissa C.

AU - Ponsonby, Anne Louise

AU - Lemeshow, Stanley

AU - Linet, Martha S.

AU - Magnus, Per

AU - Olsen, Jørn

AU - Olsen, Sjurdur F.

AU - Dwyer, Terence

AU - Stayner, Leslie T.

AU - Ward, Mary H.

AU - Consortium, on behalf of the International Childhood Cancer Cohort

PY - 2019/5

Y1 - 2019/5

N2 - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhoodcancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhoodleukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parentaloccupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 jobcodes to the ALOHA+ job exposure matrix. Risk of childhood (myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generatehazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increasedrisk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animalsHR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated withAML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNStumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significantassociations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupationalexposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALLassociated with maternal and paternal organic dust exposures should be investigated further.

AB - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhoodcancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhoodleukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parentaloccupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 jobcodes to the ALOHA+ job exposure matrix. Risk of childhood (myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generatehazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increasedrisk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animalsHR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated withAML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNStumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significantassociations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupationalexposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALLassociated with maternal and paternal organic dust exposures should be investigated further.

KW - agricultural exposures

KW - animals

KW - childhood brain tumors

KW - childhood cancer

KW - childhood leukemia

KW - organic dust

KW - parental occupation

KW - pesticides

UR - http://europepmc.org/abstract/med/31054169

U2 - 10.1002/ijc.32388

DO - 10.1002/ijc.32388

M3 - Article

C2 - 31054169

SN - 1097-0215

VL - 146

SP - 943

EP - 952

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

Abstract

Keywords

UN SDGs

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