No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

Andrés Ingason; Karen Søeby; Sally Timm; August G. Wang; Klaus D Jakobsen; Anders Fink-Jensen; Ralf Peter Arnfred Hemmingsen; Henrik Berg Rasmussen; Thomas Werge

doi:10.1016/j.schres.2005.12.850

No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

Andrés Ingason, Karen Søeby, Sally Timm, August G. Wang, Klaus D Jakobsen, Anders Fink-Jensen, Ralf Peter Arnfred Hemmingsen, Henrik Berg Rasmussen, Thomas Werge

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Schizophrenia Research
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/j.schres.2005.12.850
Publication status	Published - 2006

Keywords

case-control studies
Denmark
european continental ancestry group
genetic predisposition to disease
haplotypes
nerve tissue proteins
neuregulin-1
polymorphism
single nucleotide
schizophrenia
Ethnicity
glutamate
neurodevelopment
plasticity

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10.1016/j.schres.2005.12.850

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abstract = "Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.",

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AU - Ingason, Andrés

AU - Søeby, Karen

AU - Timm, Sally

AU - Wang, August G.

AU - Jakobsen, Klaus D

AU - Fink-Jensen, Anders

AU - Hemmingsen, Ralf Peter Arnfred

AU - Rasmussen, Henrik Berg

AU - Werge, Thomas

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AB - Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.

KW - case-control studies

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KW - haplotypes

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KW - Ethnicity

KW - glutamate

KW - neurodevelopment

KW - plasticity

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No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

Abstract

Keywords

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