No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

C Lindberg; P Koefoed; E S Hansen; T G Bolwig; J F Rehfeld; E Mellerup; O S Jørgensen; Lars Kessing; Thomas Werge; S Haugbøl; August G. Wang; D P D Woldbye

doi:10.1111/j.1600-0447.2005.00648.x

No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

C Lindberg, P Koefoed, E S Hansen, T G Bolwig, J F Rehfeld, E Mellerup, O S Jørgensen, Lars Kessing, Thomas Werge, S Haugbøl, August G. Wang, D P D Woldbye

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.

METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).

RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.

CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

Original language	English
Pages (from-to)	54-58
Number of pages	5
Journal	Acta Psychiatrica Scandinavica
Volume	113
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0447.2005.00648.x
Publication status	Published - Jan 2006

Keywords

case-control studies
neuropeptide Y
promoter regions (genetics)
single nucleotide polymorphism
schizophrenia
unipolar depression
panic disorder
DNA primers
depressive disorders
gene frequency
genotype
prevalence

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10.1111/j.1600-0447.2005.00648.x

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Lindberg, C., Koefoed, P., Hansen, E. S., Bolwig, T. G., Rehfeld, J. F., Mellerup, E., Jørgensen, O. S., Kessing, L., Werge, T., Haugbøl, S., Wang, A. G., & Woldbye, D. P. D. (2006). No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population. Acta Psychiatrica Scandinavica, 113(1), 54-58. https://doi.org/10.1111/j.1600-0447.2005.00648.x

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title = "No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population",

abstract = "OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.",

keywords = "case-control studies, neuropeptide Y, promoter regions (genetics), single nucleotide polymorphism, schizophrenia, unipolar depression, panic disorder, DNA primers, depressive disorders, gene frequency, genotype, prevalence",

author = "C Lindberg and P Koefoed and Hansen, {E S} and Bolwig, {T G} and Rehfeld, {J F} and E Mellerup and J{\o}rgensen, {O S} and Lars Kessing and Thomas Werge and S Haugb{\o}l and Wang, {August G.} and Woldbye, {D P D}",

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month = jan,

doi = "10.1111/j.1600-0447.2005.00648.x",

language = "English",

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pages = "54--58",

journal = "Acta Psychiatrica Scandinavica",

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Lindberg, C, Koefoed, P, Hansen, ES, Bolwig, TG, Rehfeld, JF, Mellerup, E, Jørgensen, OS, Kessing, L, Werge, T, Haugbøl, S, Wang, AG & Woldbye, DPD 2006, 'No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population', Acta Psychiatrica Scandinavica, vol. 113, no. 1, pp. 54-58. https://doi.org/10.1111/j.1600-0447.2005.00648.x

TY - JOUR

T1 - No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

AU - Lindberg, C

AU - Koefoed, P

AU - Hansen, E S

AU - Bolwig, T G

AU - Rehfeld, J F

AU - Mellerup, E

AU - Jørgensen, O S

AU - Kessing, Lars

AU - Werge, Thomas

AU - Haugbøl, S

AU - Wang, August G.

AU - Woldbye, D P D

PY - 2006/1

Y1 - 2006/1

N2 - OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

AB - OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

KW - case-control studies

KW - neuropeptide Y

KW - promoter regions (genetics)

KW - single nucleotide polymorphism

KW - schizophrenia

KW - unipolar depression

KW - panic disorder

KW - DNA primers

KW - depressive disorders

KW - gene frequency

KW - genotype

KW - prevalence

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U2 - 10.1111/j.1600-0447.2005.00648.x

DO - 10.1111/j.1600-0447.2005.00648.x

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C2 - 16390370

SN - 1600-0447

VL - 113

SP - 54

EP - 58

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 1

ER -

No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

Abstract

Keywords

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