No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

Nicolai A. Lund-Blix; Anne A. Bjerregaard; German Tapia; Ketil Størdal; Anne Lise Brantsæter; Marin Strøm; Thorhallur I. Halldorsson; Charlotta Granstrøm; Jannet Svensson; Geir Joner; Torild Skrivarhaug; Pål R. Njølstad; Sjurdur F. Olsen; Lars C. Stene

doi:10.1007/s00125-024-06125-4

No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

Nicolai A. Lund-Blix, Anne A. Bjerregaard, German Tapia, Ketil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I. Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R. Njølstad, Sjurdur F. Olsen, Lars C. Stene

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Aims/hypothesis The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during
pregnancy is associated with a lower risk of type 1 diabetes in children.
Methods The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa)
together include 153,843 mother–child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis
in children (n=634) was ascertained from national diabetes registries.
Results There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes
in ofspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the
DNBC. Robustness analyses gave very similar results.
Conclusions/interpretation Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in ofspring
should not be prioritised.

Original language	English
Pages (from-to)	1023–1028
Number of pages	6
Journal	Diabetologia
Volume	2024
Issue number	67
DOIs	https://doi.org/10.1007/s00125-024-06125-4
Publication status	Published - Jun 2024

Keywords

Child health
Cohort studies
Human
Intrauterine nutrition
Maternal and child health
Nutrition
Pregnancy
Type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-024-06125-4

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Lund-Blix, N. A., Bjerregaard, A. A., Tapia, G., Størdal, K., Brantsæter, A. L., Strøm, M., Halldorsson, T. I., Granstrøm, C., Svensson, J., Joner, G., Skrivarhaug, T., Njølstad, P. R., Olsen, S. F., & Stene, L. C. (2024). No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts. Diabetologia, 2024(67), 1023–1028. https://doi.org/10.1007/s00125-024-06125-4

@article{c699d18835824577a212130f799b0868,

title = "No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts",

abstract = "Aims/hypothesis The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids duringpregnancy is associated with a lower risk of type 1 diabetes in children.Methods The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa)together include 153,843 mother–child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosisin children (n=634) was ascertained from national diabetes registries.Results There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetesin ofspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and theDNBC. Robustness analyses gave very similar results.Conclusions/interpretation Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in ofspringshould not be prioritised.",

keywords = "Child health, Cohort studies, Human, Intrauterine nutrition, Maternal and child health, Nutrition, Pregnancy, Type 1 diabetes",

author = "Lund-Blix, {Nicolai A.} and Bjerregaard, {Anne A.} and German Tapia and Ketil St{\o}rdal and Brants{\ae}ter, {Anne Lise} and Marin Str{\o}m and Halldorsson, {Thorhallur I.} and Charlotta Granstr{\o}m and Jannet Svensson and Geir Joner and Torild Skrivarhaug and Nj{\o}lstad, {P{\aa}l R.} and Olsen, {Sjurdur F.} and Stene, {Lars C.}",

year = "2024",

month = jun,

doi = "10.1007/s00125-024-06125-4",

language = "English",

volume = "2024",

pages = "1023–1028",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "67",

}

Lund-Blix, NA, Bjerregaard, AA, Tapia, G, Størdal, K, Brantsæter, AL, Strøm, M, Halldorsson, TI, Granstrøm, C, Svensson, J, Joner, G, Skrivarhaug, T, Njølstad, PR, Olsen, SF & Stene, LC 2024, 'No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts', Diabetologia, vol. 2024, no. 67, pp. 1023–1028. https://doi.org/10.1007/s00125-024-06125-4

TY - JOUR

T1 - No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

AU - Lund-Blix, Nicolai A.

AU - Bjerregaard, Anne A.

AU - Tapia, German

AU - Størdal, Ketil

AU - Brantsæter, Anne Lise

AU - Strøm, Marin

AU - Halldorsson, Thorhallur I.

AU - Granstrøm, Charlotta

AU - Svensson, Jannet

AU - Joner, Geir

AU - Skrivarhaug, Torild

AU - Njølstad, Pål R.

AU - Olsen, Sjurdur F.

AU - Stene, Lars C.

PY - 2024/6

Y1 - 2024/6

N2 - Aims/hypothesis The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids duringpregnancy is associated with a lower risk of type 1 diabetes in children.Methods The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa)together include 153,843 mother–child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosisin children (n=634) was ascertained from national diabetes registries.Results There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetesin ofspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and theDNBC. Robustness analyses gave very similar results.Conclusions/interpretation Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in ofspringshould not be prioritised.

AB - Aims/hypothesis The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids duringpregnancy is associated with a lower risk of type 1 diabetes in children.Methods The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa)together include 153,843 mother–child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosisin children (n=634) was ascertained from national diabetes registries.Results There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetesin ofspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and theDNBC. Robustness analyses gave very similar results.Conclusions/interpretation Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in ofspringshould not be prioritised.

KW - Child health

KW - Cohort studies

KW - Human

KW - Intrauterine nutrition

KW - Maternal and child health

KW - Nutrition

KW - Pregnancy

KW - Type 1 diabetes

UR - https://doi.org/10.1007/s00125-024-06125-4

U2 - 10.1007/s00125-024-06125-4

DO - 10.1007/s00125-024-06125-4

M3 - Article

SN - 0012-186X

VL - 2024

SP - 1023

EP - 1028

JO - Diabetologia

JF - Diabetologia

IS - 67

ER -

No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

Abstract

Keywords

UN SDGs

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