Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication

S.-O. Mikalsen

doi:10.1016/0304-3835(90)90188-4

Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication

S.-O. Mikalsen

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication.

Original language	Undefined/Unknown
Pages (from-to)	203-208
Number of pages	6
Journal	Cancer Letters
Volume	52
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(90)90188-4
Publication status	Published - 1990
Externally published	Yes

Keywords

In vitro assays
gap junctional intercellular communication
Nitrobenzyl alcohols

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10.1016/0304-3835(90)90188-4

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title = "Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication",

abstract = "Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication.",

keywords = "In vitro assays, gap junctional intercellular communication, Nitrobenzyl alcohols",

author = "S.-O. Mikalsen",

year = "1990",

doi = "10.1016/0304-3835(90)90188-4",

language = "Undefined/Unknown",

volume = "52",

pages = "203--208",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Science direct",

number = "3",

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TY - JOUR

T1 - Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication

AU - Mikalsen, S.-O.

PY - 1990

Y1 - 1990

N2 - Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication.

AB - Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication.

KW - In vitro assays

KW - gap junctional intercellular communication

KW - Nitrobenzyl alcohols

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0025303590&partnerID=MN8TOARS

U2 - 10.1016/0304-3835(90)90188-4

DO - 10.1016/0304-3835(90)90188-4

M3 - Article

SN - 0304-3835

VL - 52

SP - 203

EP - 208

JO - Cancer Letters

JF - Cancer Letters

IS - 3

ER -

Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication

Abstract

Keywords

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