TY - JOUR
T1 - Maternal Pre-pregnancy BMI and Reproductive Health of Daughters in Young Adulthood
AU - Mariansdatter, Saga Elise
AU - Ernst, Andreas
AU - Toft, Gunnar
AU - Olsen, Sjurdur Frodi
AU - Vested, Anne
AU - Kristensen, Susanne Lund
AU - Hansen, Mette Lausten
AU - Ramlau-Hansen, Cecilia Høst
N1 - Publisher Copyright: © 2016, Springer Science+Business Media New York.
PY - 2016
Y1 - 2016
N2 - Objective To investigate the possible associations between maternal pre-pregnancy body mass index (BMI) and daughters’ age of menarche and subsequent markers of reproductive health. Methods Nine hundred eighty-five pregnant women (80 %) were enrolled at their routine 30th week examinations in 1988–1989. In 2008, a follow-up questionnaire was completed for 365 daughters (83 %), while 267 daughters (61 %) participated in a subsequent clinical examination. Main outcome measures were age of menarche, reproductive hormone profile, and ovarian follicle count in daughters. Results Daughters of mothers in the highest pre-pregnancy BMI tertile (BMI ≥ 22.0 kg/m2) had an adjusted 4.1 (0.3; 8.0) months earlier menarche compared with the middle tertile group (BMI 20.0–21.9 kg/m2). Among non-users of hormonal contraceptives, daughters of mothers in the highest pre-pregnancy BMI tertile had non-significantly lower dehydroepiandrosterone-sulphate (DHEAS), estradiol, and free estrogen index (FEI), compared to the middle BMI tertile. This was supported by a sub-analysis using the WHO classification (underweight, BMI
AB - Objective To investigate the possible associations between maternal pre-pregnancy body mass index (BMI) and daughters’ age of menarche and subsequent markers of reproductive health. Methods Nine hundred eighty-five pregnant women (80 %) were enrolled at their routine 30th week examinations in 1988–1989. In 2008, a follow-up questionnaire was completed for 365 daughters (83 %), while 267 daughters (61 %) participated in a subsequent clinical examination. Main outcome measures were age of menarche, reproductive hormone profile, and ovarian follicle count in daughters. Results Daughters of mothers in the highest pre-pregnancy BMI tertile (BMI ≥ 22.0 kg/m2) had an adjusted 4.1 (0.3; 8.0) months earlier menarche compared with the middle tertile group (BMI 20.0–21.9 kg/m2). Among non-users of hormonal contraceptives, daughters of mothers in the highest pre-pregnancy BMI tertile had non-significantly lower dehydroepiandrosterone-sulphate (DHEAS), estradiol, and free estrogen index (FEI), compared to the middle BMI tertile. This was supported by a sub-analysis using the WHO classification (underweight, BMI
KW - BMI
KW - Female reproduction
KW - Follow-up
KW - Menarche
KW - Prenatal exposure
U2 - 10.1007/s10995-016-2062-5
DO - 10.1007/s10995-016-2062-5
M3 - Article
SN - 1092-7875
VL - 20
SP - 2150
EP - 2159
JO - Maternal and Child Health Journal
JF - Maternal and Child Health Journal
IS - 10
ER -