TY - JOUR
T1 - Maternal Diet, Gestational Weight Gain, and Inflammatory Markers During Pregnancy
AU - Hrolfsdottir, Laufey
AU - Schalkwijk, Casper G
AU - Birgisdottir, Bryndis E
AU - Gunnarsdottir, Ingibjørg
AU - Maslova, Ekaterina
AU - Granstrom, Charlotta
AU - Strøm, Marin
AU - Olsen, SF
AU - Halldorsson, Thorhallur I
PY - 2016
Y1 - 2016
N2 - ObjectiveTo examine the associations of gestational weight gain (GWG) and diet with low-grade inflammation in pregnancy.MethodsA cross-sectional analysis of 671 pregnant women was performed, and diet was assessed in gestational week 30. GWG was recorded in weeks 30 and ∼37 (difference between the weight recorded at these time points and pre-pregnancy weight). Markers of inflammation, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), interleukin (IL)−6, IL-8, IL-1β, and tumor necrosis factor-α were quantified in serum from week 30.ResultsAfter adjusting for age, pre-pregnancy BMI, parity, smoking status, and education, each 1 kg increase in GWG was associated with 3% (95% CI: 1–5) higher hsCRP and 3% (95% CI: 1–4) higher SAA concentrations, which corresponded to ∼18% to 25% increase in these biomarkers among those with excessive weight gain. GWG was inversely associated with IL-8 while no associations were found for the other inflammatory markers. With respect to diet, women in the highest compared with lowest quintile of protein intake had 26% (95% CI: 3–54) higher hsCRP concentrations. This increase appeared to be driven by intake of animal protein. A similar pattern was observed for SAA.ConclusionsExcessive GWG, as well as high intake of animal protein, was associated with higher concentrations of inflammatory factors.
AB - ObjectiveTo examine the associations of gestational weight gain (GWG) and diet with low-grade inflammation in pregnancy.MethodsA cross-sectional analysis of 671 pregnant women was performed, and diet was assessed in gestational week 30. GWG was recorded in weeks 30 and ∼37 (difference between the weight recorded at these time points and pre-pregnancy weight). Markers of inflammation, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), interleukin (IL)−6, IL-8, IL-1β, and tumor necrosis factor-α were quantified in serum from week 30.ResultsAfter adjusting for age, pre-pregnancy BMI, parity, smoking status, and education, each 1 kg increase in GWG was associated with 3% (95% CI: 1–5) higher hsCRP and 3% (95% CI: 1–4) higher SAA concentrations, which corresponded to ∼18% to 25% increase in these biomarkers among those with excessive weight gain. GWG was inversely associated with IL-8 while no associations were found for the other inflammatory markers. With respect to diet, women in the highest compared with lowest quintile of protein intake had 26% (95% CI: 3–54) higher hsCRP concentrations. This increase appeared to be driven by intake of animal protein. A similar pattern was observed for SAA.ConclusionsExcessive GWG, as well as high intake of animal protein, was associated with higher concentrations of inflammatory factors.
U2 - 10.1002/oby.21617
DO - 10.1002/oby.21617
M3 - Article
SN - 1930-7381
VL - 24
SP - 2133
EP - 2139
JO - Obesity
JF - Obesity
IS - 10
ER -