TY - JOUR
T1 - Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes
AU - Kampmann, Freja Bach
AU - Thuesen, Anne Cathrine Baun
AU - Hjort, Line
AU - Bjerregaard, Anne Ahrendt
AU - Chavarro, Jorge
AU - Frystyk, Jan
AU - Bjerre, Mette
AU - Tetens, Inge
AU - Olsen, Sjurdur F
AU - Vaag, Allan
AU - Damm, Peter
AU - Grunnet, Louise Groth
N1 - CURIS 2019 NEXS 369
PY - 2019
Y1 - 2019
N2 - Objective: Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponectin, and FGF21 concentrations and their associations with measures of adiposity and metabolic traits during childhood/adolescence.Design and Methods: The follow-up study included 504 GDM and 540 control offspring aged 9-16 from the Danish National Birth Cohort. Anthropometric measurements, fasting blood samples, puberty status and fat percentages by Dual-energy x-ray absorptiometry were examined. Serum concentrations of leptin, adiponectin, and FGF21 were measured by validated immune assays.Results: GDM offspring had 38% (95% CI: 22-55%) higher leptin, 0.6mg/L (95% CI -1.2, -0.04mg/L) lower adiponectin, and 32% (95% CI: -47%, -12%) lower FGF21 concentrations than control offspring (p
AB - Objective: Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponectin, and FGF21 concentrations and their associations with measures of adiposity and metabolic traits during childhood/adolescence.Design and Methods: The follow-up study included 504 GDM and 540 control offspring aged 9-16 from the Danish National Birth Cohort. Anthropometric measurements, fasting blood samples, puberty status and fat percentages by Dual-energy x-ray absorptiometry were examined. Serum concentrations of leptin, adiponectin, and FGF21 were measured by validated immune assays.Results: GDM offspring had 38% (95% CI: 22-55%) higher leptin, 0.6mg/L (95% CI -1.2, -0.04mg/L) lower adiponectin, and 32% (95% CI: -47%, -12%) lower FGF21 concentrations than control offspring (p
KW - Adiponectin
KW - Adiposity
KW - Developmental programming
KW - Fibroblast growth factor 21
KW - Gestational diabetes mellitus
KW - Leptin
KW - Offspring metabolic health
U2 - 10.1530/EJE-19-0658
DO - 10.1530/EJE-19-0658
M3 - Article
SN - 0804-4643
VL - 181
SP - 691
EP - 700
JO - European journal of endocrinology
JF - European journal of endocrinology
IS - 6
ER -
