TY - JOUR
T1 - Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes
T2 - findings from two independent populations
AU - Li, Mengying
AU - Rahman, Mohammad L.
AU - Wu, Jing
AU - Ding, Ming
AU - Chavarro, Jorge E.
AU - Lin, Yuan
AU - Ley, Sylvia H.
AU - Bao, Wei
AU - Grunnet, Louise G.
AU - Hinkle, Stefanie N.
AU - Thuesen, Anne Cathrine B.
AU - Yeung, Edwina
AU - Gore-Langton, Robert E.
AU - Sherman, Seth
AU - Hjort, Line
AU - Kampmann, Freja Bach
AU - Bjerregaard, Anne Ahrendt
AU - Damm, Peter
AU - Tekola-Ayele, Fasil
AU - Liu, Aiyi
AU - Mills, James L.
AU - Vaag, Allan
AU - Olsen, Sjurdur F.
AU - Hu, Frank B.
AU - Zhang, Cuilin
N1 - M1 - e000850
PY - 2020/2
Y1 - 2020/2
N2 - Objective Women with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D. Research design and methods This cohort study included 2434 white women with a history of GDM from the Nurses' Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alternate healthy eating index (AHEI) score was derived to reflect dietary quality after the pregnancy affected by GDM. Results Women on average were followed for 21 years in NHSII and 13 years in DNBC, during which 446 (23.7%) and 155 (28.2%) developed T2D, respectively. The GRS was generally positively associated with T2D risk in both cohorts. In the pooled analysis, the relative risks (RRs) for increasing quartiles of GRS were 1.00, 0.97, 1.25 and 1.19 (p trend=0.02). In both cohorts, the association appeared to be stronger among women with poorer (AHEI
AB - Objective Women with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D. Research design and methods This cohort study included 2434 white women with a history of GDM from the Nurses' Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alternate healthy eating index (AHEI) score was derived to reflect dietary quality after the pregnancy affected by GDM. Results Women on average were followed for 21 years in NHSII and 13 years in DNBC, during which 446 (23.7%) and 155 (28.2%) developed T2D, respectively. The GRS was generally positively associated with T2D risk in both cohorts. In the pooled analysis, the relative risks (RRs) for increasing quartiles of GRS were 1.00, 0.97, 1.25 and 1.19 (p trend=0.02). In both cohorts, the association appeared to be stronger among women with poorer (AHEI
KW - dietary quality
KW - genetic risk score
KW - gestational diabetes
KW - prospective cohort studies
KW - type 2 diabetes
U2 - 10.1136/bmjdrc-2019-000850
DO - 10.1136/bmjdrc-2019-000850
M3 - Article
SN - 2052-4897
VL - 8
JO - BMJ open diabetes research & care
JF - BMJ open diabetes research & care
IS - 1
ER -
