Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise

Jeppe F. Vigh-Larsen; Niels Ørtenblad; Ole Emil Andersen; Hallur Thorsteinsson; Thea H. Kristiansen; Stine Bilde; Mads S. Mikkelsen; Joachim Nielsen; Magni Mohr; Kristian Overgaard

doi:10.1113/JP283225

Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise

Jeppe F. Vigh-Larsen, Niels Ørtenblad, Ole Emil Andersen, Hallur Thorsteinsson, Thea H. Kristiansen, Stine Bilde, Mads S. Mikkelsen, Joachim Nielsen, Magni Mohr, Kristian Overgaard

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

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Abstract

Abstract: Glycogen particles are situated in key areas of the muscle cell in the vicinity of the main energy-consumption sites and may be utilised heterogeneously dependent on the nature of the metabolic demands. The present study aimed to investigate the time course of fibre type-specific utilisation of muscle glycogen in three distinct subcellular fractions (intermyofibrillar, IMF; intramyofibrillar, Intra; and subsarcolemmal, SS) during repeated high-intensity intermittent exercise. Eighteen moderately to well-trained male participants performed three periods of 10 × 45 s cycling at ∼105% watt max (EX1–EX3) coupled with 5 × 6 s maximal sprints at baseline and after each period. Muscle biopsies were sampled at baseline and after EX1 and EX3. A higher glycogen breakdown rate in type 2 compared to type 1 fibres was found during EX1 for the Intra (−72 vs. −45%) and IMF (−59 vs. −35%) glycogen fractions (P

Original language	English
Article number	JP283225
Pages (from-to)	1-18
Number of pages	18
Journal	The Journal of physiology
Volume	n/a
Issue number	n/a
DOIs	https://doi.org/10.1113/JP283225
Publication status	Published - Aug 2022

Keywords

carbohydrate
excitation–contraction coupling
fatigue
metabolism
performance
subcellular

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Vigh‐Larsen et al Fibre type_and localisation‐specific muscle glycogen utilisation duringFinal published version, 1.79 MBLicence: CC BY-NC-ND

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Vigh-Larsen, J. F., Ørtenblad, N., Emil Andersen, O., Thorsteinsson, H., Kristiansen, T. H., Bilde, S., Mikkelsen, M. S., Nielsen, J., Mohr, M., & Overgaard, K. (2022). Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise. The Journal of physiology, n/a(n/a), 1-18. Article JP283225. https://doi.org/10.1113/JP283225

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abstract = "Abstract: Glycogen particles are situated in key areas of the muscle cell in the vicinity of the main energy-consumption sites and may be utilised heterogeneously dependent on the nature of the metabolic demands. The present study aimed to investigate the time course of fibre type-specific utilisation of muscle glycogen in three distinct subcellular fractions (intermyofibrillar, IMF; intramyofibrillar, Intra; and subsarcolemmal, SS) during repeated high-intensity intermittent exercise. Eighteen moderately to well-trained male participants performed three periods of 10 × 45 s cycling at ∼105% watt max (EX1–EX3) coupled with 5 × 6 s maximal sprints at baseline and after each period. Muscle biopsies were sampled at baseline and after EX1 and EX3. A higher glycogen breakdown rate in type 2 compared to type 1 fibres was found during EX1 for the Intra (−72 vs. −45%) and IMF (−59 vs. −35%) glycogen fractions (P ",

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author = "Vigh-Larsen, {Jeppe F.} and Niels {\O}rtenblad and {Emil Andersen}, Ole and Hallur Thorsteinsson and Kristiansen, {Thea H.} and Stine Bilde and Mikkelsen, {Mads S.} and Joachim Nielsen and Magni Mohr and Kristian Overgaard",

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Vigh-Larsen, JF, Ørtenblad, N, Emil Andersen, O, Thorsteinsson, H, Kristiansen, TH, Bilde, S, Mikkelsen, MS, Nielsen, J, Mohr, M & Overgaard, K 2022, 'Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise', The Journal of physiology, vol. n/a, no. n/a, JP283225, pp. 1-18. https://doi.org/10.1113/JP283225

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AU - Ørtenblad, Niels

AU - Emil Andersen, Ole

AU - Thorsteinsson, Hallur

AU - Kristiansen, Thea H.

AU - Bilde, Stine

AU - Mikkelsen, Mads S.

AU - Nielsen, Joachim

AU - Mohr, Magni

AU - Overgaard, Kristian

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PY - 2022/8

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N2 - Abstract: Glycogen particles are situated in key areas of the muscle cell in the vicinity of the main energy-consumption sites and may be utilised heterogeneously dependent on the nature of the metabolic demands. The present study aimed to investigate the time course of fibre type-specific utilisation of muscle glycogen in three distinct subcellular fractions (intermyofibrillar, IMF; intramyofibrillar, Intra; and subsarcolemmal, SS) during repeated high-intensity intermittent exercise. Eighteen moderately to well-trained male participants performed three periods of 10 × 45 s cycling at ∼105% watt max (EX1–EX3) coupled with 5 × 6 s maximal sprints at baseline and after each period. Muscle biopsies were sampled at baseline and after EX1 and EX3. A higher glycogen breakdown rate in type 2 compared to type 1 fibres was found during EX1 for the Intra (−72 vs. −45%) and IMF (−59 vs. −35%) glycogen fractions (P

AB - Abstract: Glycogen particles are situated in key areas of the muscle cell in the vicinity of the main energy-consumption sites and may be utilised heterogeneously dependent on the nature of the metabolic demands. The present study aimed to investigate the time course of fibre type-specific utilisation of muscle glycogen in three distinct subcellular fractions (intermyofibrillar, IMF; intramyofibrillar, Intra; and subsarcolemmal, SS) during repeated high-intensity intermittent exercise. Eighteen moderately to well-trained male participants performed three periods of 10 × 45 s cycling at ∼105% watt max (EX1–EX3) coupled with 5 × 6 s maximal sprints at baseline and after each period. Muscle biopsies were sampled at baseline and after EX1 and EX3. A higher glycogen breakdown rate in type 2 compared to type 1 fibres was found during EX1 for the Intra (−72 vs. −45%) and IMF (−59 vs. −35%) glycogen fractions (P

KW - carbohydrate

KW - excitation–contraction coupling

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KW - performance

KW - subcellular

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Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise

Abstract

Keywords

UN SDGs

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