TY - JOUR
T1 - Feasibility and impact of whole-body high-intensity interval training in patients with stable coronary artery disease
T2 - a randomised controlled trial
AU - Kristiansen, Jacobina
AU - Sjúrðarson, Tórur
AU - Grove, Erik Lerkevang
AU - Rasmussen, Jan
AU - Kristensen, Steen Dalby
AU - Hvas, Anne-Mette
AU - Mohr, Magni
PY - 2022/10/14
Y1 - 2022/10/14
N2 - Exercise training reduces cardiovascular mortality and improves quality of life in CAD patients. We investigated the feasibility and impact of 12 weeks of low-volume high-intensity interval training (HIIT) in CAD-patients. Patients with stable CAD were randomized 1:1 to supervised HIIT or standard care. HIIT sessions were completed three times weekly for 12 weeks on a rowing ergometer. Before and after the 12-week intervention, patients completed a physiological evaluation of cardiorespiratory performance and quality of life questionnaires. Mixed model analysis was used to evaluate differences between and within groups. A total of 142 patients (67 ± 9 years, nHIIT = 64, nStandard care = 78) completed the trial. Training adherence was 97% (range 86–100%). Six patients dropped out because of non-fatal adverse events. Weekly training duration was 54 min with an average power output of 138 W. HIIT increased peak oxygen uptake by 2.5 mL/kg/min (95% CI 2.1–3.0), whereas no change was observed in standard care (0.2 mL/kg/min, 95% CI − 0.2–0.6, P
AB - Exercise training reduces cardiovascular mortality and improves quality of life in CAD patients. We investigated the feasibility and impact of 12 weeks of low-volume high-intensity interval training (HIIT) in CAD-patients. Patients with stable CAD were randomized 1:1 to supervised HIIT or standard care. HIIT sessions were completed three times weekly for 12 weeks on a rowing ergometer. Before and after the 12-week intervention, patients completed a physiological evaluation of cardiorespiratory performance and quality of life questionnaires. Mixed model analysis was used to evaluate differences between and within groups. A total of 142 patients (67 ± 9 years, nHIIT = 64, nStandard care = 78) completed the trial. Training adherence was 97% (range 86–100%). Six patients dropped out because of non-fatal adverse events. Weekly training duration was 54 min with an average power output of 138 W. HIIT increased peak oxygen uptake by 2.5 mL/kg/min (95% CI 2.1–3.0), whereas no change was observed in standard care (0.2 mL/kg/min, 95% CI − 0.2–0.6, P
KW - exercise training
KW - cardiovascular mortality
KW - cardiovascular health
KW - Coronary artery disease
U2 - 10.1038/s41598-022-21655-w
DO - 10.1038/s41598-022-21655-w
M3 - Article
SN - 2045-2322
VL - 12
SP - 17295
JO - SCIENTIFIC REPORTS
JF - SCIENTIFIC REPORTS
IS - 1
ER -