TY - JOUR
T1 - Effects of hydrocarbons on transformation and intercellular communication in Syrian hamster embryo cells
AU - Rivedal, E.
AU - Mikalsen, S.‐O.
AU - Roseng, L.E.
AU - Sanner, T.
AU - Eide, I.
PY - 1992
Y1 - 1992
N2 - The ability of 18 different hydrocarbons to induce and promote morphological transformation and to inhibit intercellular communication in primary Syrian hamster embryo cells in culture have been studied. The compounds were: the n-alkanes octane, nonane, decane, undecane, dodecane and tridecane; the iso-alkanes 2-methylheptane, 2-methyloctane and 2-methylnonane; the naphthenes 1,2-dimethylcyclohexane, 1,2,4-trimethylcyclohexane and tert-butylcyclohexane; the aromates 1,2-dimethylbenzene, 1,2,4-trimetylbenzene and tert-butylbenzene; and the alkenes 1-octene, 1-nonene and 1-decene. None of the hydrocarbons induced morphological transformation of Syrian hamster embryo cells. When the hydrocarbons were incubated together with benzo(a)pyrene, enhancement of the transformation frequency was observed for the naphthene 1,2-dimethylcyclohexane and the iso-alkanes 2-methylheptane and 2-methyloctane. None of the n-alkanes, alkenes or aromates enhanced the transformation frequency induced by benzo(a)pyrene. The alkane tridecane and the iso-alkanes 2-methyloctane and 2-methylnonane reduced intercellular communication in the primary Syrian hamster embryo cells.
AB - The ability of 18 different hydrocarbons to induce and promote morphological transformation and to inhibit intercellular communication in primary Syrian hamster embryo cells in culture have been studied. The compounds were: the n-alkanes octane, nonane, decane, undecane, dodecane and tridecane; the iso-alkanes 2-methylheptane, 2-methyloctane and 2-methylnonane; the naphthenes 1,2-dimethylcyclohexane, 1,2,4-trimethylcyclohexane and tert-butylcyclohexane; the aromates 1,2-dimethylbenzene, 1,2,4-trimetylbenzene and tert-butylbenzene; and the alkenes 1-octene, 1-nonene and 1-decene. None of the hydrocarbons induced morphological transformation of Syrian hamster embryo cells. When the hydrocarbons were incubated together with benzo(a)pyrene, enhancement of the transformation frequency was observed for the naphthene 1,2-dimethylcyclohexane and the iso-alkanes 2-methylheptane and 2-methyloctane. None of the n-alkanes, alkenes or aromates enhanced the transformation frequency induced by benzo(a)pyrene. The alkane tridecane and the iso-alkanes 2-methyloctane and 2-methylnonane reduced intercellular communication in the primary Syrian hamster embryo cells.
KW - Embryo Cells
KW - Hydrocarbons
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0026763410&partnerID=MN8TOARS
U2 - 10.1111/j.1600-0773.1992.tb00521.x
DO - 10.1111/j.1600-0773.1992.tb00521.x
M3 - Article
SN - 2152-100x
VL - 71
SP - 57
EP - 61
JO - Pharmacology and Toxicology
JF - Pharmacology and Toxicology
IS - 1
ER -