Abstract
Background: Previous studies have indicated that intake of fish oils during pregnancy may protect against devel-opment of child asthma. It has also been suggested that micro-flora exposure associated with a normal vaginal delivery may modify the child’s susceptibility of develop-ing asthma.
Objective: To examine the association between fish oilduring pregnancy and child asthma and interaction withtype of delivery in a group of twin pregnancies with a relatively high rate of caesarean (C-) sections.
Methods: We used data from a multicenter randomized controlled trial (FOTIP) 306 mothers with twin pregnancies were randomized to fish oil (2.7 g/d of n-3 fattyacids) or olive oil during the latter half of pregnancy. Delivery mode (vaginal vs. C-section) was recorded. Child asthma diagnosis was obtained from the Danish National Patient Registry using ICD-8 and ICD-10 codes. We performed intention-to-treat analyses and used logistic regression models to calculate odds ratios (OR) and 95%CIs adjusting for correlated data among twin pairs. Results: Vaginal deliveries were recorded in 39% and C-section in 61% of the deliveries. By 2008, 7% of children in the fish oil group and 10% in the olive oil group had received a registry asthma diagnosis. The OR of an asthma diagnosis in the fish oil vs. olive oil group was 0.71 (95% CI: 0.37–1.36). Looking at interaction by delivery mode we found an increased risk of asthma in off-spring delivered by C-section (OR=3.7 (1.1–11.7) in the fish oil group, OR=4.7 (1.6–13.7) in the olive oil group) compared to offspring delivered vaginally in the fish oilgroup.
Conclusions: We found evidence of a non-significant protective effect of maternal fish oil on offspring asthma diagnosis. When we looked at interaction by deliverymode, a significant increased risk of asthma was found in offspring delivered by C-section; this association seemed to be modified to some extent by fish oil. Future studies including other means of ascertaining offspring asthma aswell as allergies are needed.
Objective: To examine the association between fish oilduring pregnancy and child asthma and interaction withtype of delivery in a group of twin pregnancies with a relatively high rate of caesarean (C-) sections.
Methods: We used data from a multicenter randomized controlled trial (FOTIP) 306 mothers with twin pregnancies were randomized to fish oil (2.7 g/d of n-3 fattyacids) or olive oil during the latter half of pregnancy. Delivery mode (vaginal vs. C-section) was recorded. Child asthma diagnosis was obtained from the Danish National Patient Registry using ICD-8 and ICD-10 codes. We performed intention-to-treat analyses and used logistic regression models to calculate odds ratios (OR) and 95%CIs adjusting for correlated data among twin pairs. Results: Vaginal deliveries were recorded in 39% and C-section in 61% of the deliveries. By 2008, 7% of children in the fish oil group and 10% in the olive oil group had received a registry asthma diagnosis. The OR of an asthma diagnosis in the fish oil vs. olive oil group was 0.71 (95% CI: 0.37–1.36). Looking at interaction by delivery mode we found an increased risk of asthma in off-spring delivered by C-section (OR=3.7 (1.1–11.7) in the fish oil group, OR=4.7 (1.6–13.7) in the olive oil group) compared to offspring delivered vaginally in the fish oilgroup.
Conclusions: We found evidence of a non-significant protective effect of maternal fish oil on offspring asthma diagnosis. When we looked at interaction by deliverymode, a significant increased risk of asthma was found in offspring delivered by C-section; this association seemed to be modified to some extent by fish oil. Future studies including other means of ascertaining offspring asthma aswell as allergies are needed.
| Original language | English |
|---|---|
| Pages (from-to) | 17 |
| Number of pages | 1 |
| Journal | Acta obstetricia et gynecologica Scandinavica |
| Volume | 92 |
| Issue number | s160 |
| DOIs | |
| Publication status | Published - 2013 |