Consequences of exposure measurement error for confounder identification in environmental epidemiology

Esben Budtz-Jørgensen, Niels Keiding, Philippe Grandjean, Pal Weihe, Roberta F. White

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)

    Abstract

    Non-differential measurement error in the exposure variable is known to attenuate the dose-response relationship. The amount of attenuation introduced in a given situation is not only a function of the precision of the exposure measurement but also depends on the conditional variance of the true exposure given the other independent variables. In addition, confounder effects may also be affected by the exposure measurement error. These difficulties in statistical model development are illustrated by examples from a epidemiological study performed in the Faroe Islands to investigate adverse health effects of prenatal mercury exposure. Copyright © 2003 John Wiley & Sons, Ltd.
    Original languageEnglish
    Pages (from-to)3089-3100
    Number of pages12
    JournalStatistics in Medicine
    Volume22
    Issue number19
    Early online date8 Sept 2003
    DOIs
    Publication statusPublished - Oct 2003

    Keywords

    • Bias
    • Confounding
    • Factor analysis
    • Instrumental variables
    • Measurement error
    • Multiple regression

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