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Abstract
Background The incidence and prevalence of infammatory bowel disease (IBD) in the Faroe Islands have increased drastically during the past 60 years, presumably due to changing environmental risk factors in a genetically susceptible population.
Aim This study investigated difering environmental factors present in Faroese and Danish patients.
Methods From 2010 to 2022, all incident Faroese patients with IBD were invited to complete the International Organization
of IBD (IOIBD) questionnaire about environmental factors at the time of their diagnosis. The fndings were compared to a
cohort of incident Danish patients diagnosed between 2010 and 2011.
Results Questionnaires were completed by 293 of 388 Faroese patients (75%), of whom 15% (n=45) had Crohn’s disease
(CD), 63% (n=185) had ulcerative colitis (UC), and 22% (n=63) had IBD unclassifed (IBDU). Faroese patients with IBD
and UC were found to have higher pertussis vaccination coverage (p<0.05), and more childhood infections of measles and
pertussis (p<0.05). Faroese patients with IBD consumed more fast food and less fber but consumed less sugar (p<0.001)
and more cafeine (p<0.001). No diferences were found regarding gender, having been breastfed, use of oral contraceptives, or the number of frst-degree relatives with IBD; however, diferences in smoking at diagnosis were found in a subset
analysis of Faroese patients diagnosed in 2010–11 compared with Danish patients.
Conclusions Faroese patients with IBD were more exposed to some environmental risk factors prior to diagnosis than Danish
patients. However, certain benefcial dietary habits were more common in Faroese patients than in Danish patients
Aim This study investigated difering environmental factors present in Faroese and Danish patients.
Methods From 2010 to 2022, all incident Faroese patients with IBD were invited to complete the International Organization
of IBD (IOIBD) questionnaire about environmental factors at the time of their diagnosis. The fndings were compared to a
cohort of incident Danish patients diagnosed between 2010 and 2011.
Results Questionnaires were completed by 293 of 388 Faroese patients (75%), of whom 15% (n=45) had Crohn’s disease
(CD), 63% (n=185) had ulcerative colitis (UC), and 22% (n=63) had IBD unclassifed (IBDU). Faroese patients with IBD
and UC were found to have higher pertussis vaccination coverage (p<0.05), and more childhood infections of measles and
pertussis (p<0.05). Faroese patients with IBD consumed more fast food and less fber but consumed less sugar (p<0.001)
and more cafeine (p<0.001). No diferences were found regarding gender, having been breastfed, use of oral contraceptives, or the number of frst-degree relatives with IBD; however, diferences in smoking at diagnosis were found in a subset
analysis of Faroese patients diagnosed in 2010–11 compared with Danish patients.
Conclusions Faroese patients with IBD were more exposed to some environmental risk factors prior to diagnosis than Danish
patients. However, certain benefcial dietary habits were more common in Faroese patients than in Danish patients
Original language | English |
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Journal | Digestive Diseases and Sciences |
DOIs | |
Publication status | Published - 14 Nov 2024 |
Keywords
- Faroe Islands · Infammatory bowel disease · Environmental factors · Ulcerative colitis · Crohn’s disease
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Dive into the research topics of 'Comparing Environmental Risk Factors at Diagnosis in Faroese and Danish Patients with Inflammatory Bowel Disease.'. Together they form a unique fingerprint.Projects
- 1 Finished
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Causes and costs of the high incidence of Inflammatory Bowel Disease in the Faroe Islands
Hammer, T. (PI), Petersen, M. S. (CoI), Strøm, M. (CoI), Weihe, P. M. (CoI), Nielsen, K. R. (CoI), Midjord, J. (CoI), Vang, A. (CoI), Lophaven, S. N. (CoI), Burisch, J. (CoI) & Langholz, E. (CoI)
1/03/21 → 1/07/24
Project: Research