Benchmark dose calculations of methylmercury-associated neurobehavioural deficits

Esben Budtz-Jørgensen; Philippe Grandjean; Niels Keiding; Roberta F. White; Pal Weihe

doi:10.1016/S0378-4274(99)00283-0

Benchmark dose calculations of methylmercury-associated neurobehavioural deficits

Esben Budtz-Jørgensen, Philippe Grandjean, Niels Keiding, Roberta F. White, Pal Weihe

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury concentration as the dose parameter, a logarithmic dose-response model tended to show a better fit than a linear dose model for the attention, language and verbal memory tests. The lowest BMDLs averaged ~5 μg/l cord blood, which corresponds to a maternal hair concentration of ~1 μg/g. However, most BMDLs for hair mercury concentrations were higher. Thus, the results of the benchmark calculations depend on the assumed dose-response model. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	193-199
Number of pages	7
Journal	Toxicology Letters
Volume	112-113
DOIs	https://doi.org/10.1016/S0378-4274(99)00283-0
Publication status	Published - 15 Mar 2000

Keywords

Food contamination
Prenatal exposure delayed effects
Risk assessment

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10.1016/S0378-4274(99)00283-0

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title = "Benchmark dose calculations of methylmercury-associated neurobehavioural deficits",

abstract = "Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury concentration as the dose parameter, a logarithmic dose-response model tended to show a better fit than a linear dose model for the attention, language and verbal memory tests. The lowest BMDLs averaged ~5 μg/l cord blood, which corresponds to a maternal hair concentration of ~1 μg/g. However, most BMDLs for hair mercury concentrations were higher. Thus, the results of the benchmark calculations depend on the assumed dose-response model. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

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AU - Budtz-Jørgensen, Esben

AU - Grandjean, Philippe

AU - Keiding, Niels

AU - White, Roberta F.

AU - Weihe, Pal

PY - 2000/3/15

Y1 - 2000/3/15

N2 - Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury concentration as the dose parameter, a logarithmic dose-response model tended to show a better fit than a linear dose model for the attention, language and verbal memory tests. The lowest BMDLs averaged ~5 μg/l cord blood, which corresponds to a maternal hair concentration of ~1 μg/g. However, most BMDLs for hair mercury concentrations were higher. Thus, the results of the benchmark calculations depend on the assumed dose-response model. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury concentration as the dose parameter, a logarithmic dose-response model tended to show a better fit than a linear dose model for the attention, language and verbal memory tests. The lowest BMDLs averaged ~5 μg/l cord blood, which corresponds to a maternal hair concentration of ~1 μg/g. However, most BMDLs for hair mercury concentrations were higher. Thus, the results of the benchmark calculations depend on the assumed dose-response model. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Food contamination

KW - Prenatal exposure delayed effects

KW - Risk assessment

U2 - 10.1016/S0378-4274(99)00283-0

DO - 10.1016/S0378-4274(99)00283-0

M3 - Article

SN - 0378-4274

VL - 112-113

SP - 193

EP - 199

JO - Toxicology Letters

JF - Toxicology Letters

ER -

Benchmark dose calculations of methylmercury-associated neurobehavioural deficits

Abstract

Keywords

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