Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption

Kathryn R. Mahaffey, Elsie M. Sunderland, Hing Man Chan, Anna L. Choi, Philippe Grandjean, Koenraad Mariën, Emily Oken, Mineshi Sakamoto, Rita Schoeny, Pál Weihe, Chong-Huai Yan, Akira Yasutake

    Research output: Contribution to journalArticlepeer-review

    210 Citations (Scopus)

    Abstract

    Fish and shellfish are widely available foods that provide important nutrients, particularly n-3 polyunsaturated fatty acids (n-3 PUFAs), to many populations globally. These nutrients, especially docosahexaenoic acid, confer benefits to brain and visual system development in infants and reduce risks of certain forms of heart disease in adults. However, fish and shellfish can also be a major source of methylmercury (MeHg), a known neurotoxicant that is particularly harmful to fetal brain development. This review documents the latest knowledge on the risks and benefits of seafood consumption for perinatal development of infants. It is possible to choose fish species that are both high in n-3 PUFAs and low in MeHg. A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested.
    Original languageEnglish
    Pages (from-to)493-508
    Number of pages16
    JournalNutrition Reviews
    Volume69
    Issue number9
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Docosahexaenoic acid
    • Eicosapentaenoic acid
    • Fish
    • Methylmercury
    • N-3 polyunsaturated fatty acids

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