Are TMEM genes potential candidate genes for panic disorder?

Noomi Gregersen; Henriette Nørmølle Buttenschøn; Anne Hedemand; Hans Atli Dahl; Ann Suhl Kristensen; Birita Clementsen; David P D Woldbye; Pernille Koefoed; Angelika Erhardt; Torben A Kruse; August G. Wang; Anders Børglum; Ole Mors

doi:10.1097/YPG.0000000000000022

Are TMEM genes potential candidate genes for panic disorder?

Noomi Gregersen, Henriette Nørmølle Buttenschøn, Anne Hedemand, Hans Atli Dahl, Ann Suhl Kristensen, Birita Clementsen, David P D Woldbye, Pernille Koefoed, Angelika Erhardt, Torben A Kruse, August G. Wang, Anders Børglum, Ole Mors

Deildin fyri heilsu- og sjúkrarøktarvísindi - Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.

Original language	English
Pages (from-to)	37-41
Number of pages	5
Journal	Psychiatric Genetics
Volume	24
Issue number	1
DOIs	https://doi.org/10.1097/YPG.0000000000000022
Publication status	Published - Feb 2014

Keywords

association
candidate genes
chromosome 17q
panic disorder
single nucleotide polymorphism
TMEM

Access to Document

10.1097/YPG.0000000000000022

Cite this

@article{37d9285ac78241119c38067f94436da3,

title = "Are TMEM genes potential candidate genes for panic disorder?",

abstract = "We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.",

keywords = "association, candidate genes, chromosome 17q, panic disorder, single nucleotide polymorphism, TMEM",

author = "Noomi Gregersen and Buttensch{\o}n, {Henriette N{\o}rm{\o}lle} and Anne Hedemand and Dahl, {Hans Atli} and Kristensen, {Ann Suhl} and Birita Clementsen and Woldbye, {David P D} and Pernille Koefoed and Angelika Erhardt and Kruse, {Torben A} and Wang, {August G.} and Anders B{\o}rglum and Ole Mors",

year = "2014",

month = feb,

doi = "10.1097/YPG.0000000000000022",

language = "English",

volume = "24",

pages = "37--41",

journal = "Psychiatric Genetics",

issn = "1473-5873",