0360 - Impact of statin withdrawal for exercise training adaptability in statin-dependent patients

Project Details

Description

Introduction
Patients with dyslipidaemia are often prescribed statins, which efficiently lower plasma low-density lipoprotein cholesterol. However, statins have frequently been associated with muscle complaints and may counteract the up-regulated mitochondrial biogenesis and function, as well as the cardiovascular capacity accrued with exercise training. Thus, the aim of the present research proposal is to investigate whether periodization of statin treatment can make exercise training more tolerable and improve the health-beneficial outcome of exercise training in patients with dyslipidaemia.

Methods and analysis
The study is designed as a 12-week, double-blinded, randomised, placebo-controlled trial. A total of 100 women and men (aged 45-65 years) diagnosed with dyslipidaemia will be randomised in a 1:1:1:1 ratio to one of four study arms for 12 weeks: 1) placebo, 2) exercise + placebo, 3) atorvastatin (40 mg/day) and 4) exercise + atorvastatin (40 mg/day). The primary endpoint is change in mitochondrial function from baseline to post-intervention.

Dissemination
The results from the study, which are expected to clarify the interaction between statin treatment and exercise training on several psychological and physiological key-components relevant for general health status in patients with dyslipidemia, will be published in international peer-review journals.
Short titleExercise and statins
StatusActive
Effective start/end date1/05/241/05/25

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